Please note the schedule for the exam dates. There are two in-class (1 hour) closed-book midterm quizzes scheduled for the term. Students are encouraged to use this to their benefit, to accommodate special situations such as interview travel/illness. Instead, we will not use 2 lowest homework grades (out of 9 total) for the calculation of the term homework grade (30%). We will not accept late homework for any reason. Solutions will be provided on-line after the due date and time. Homework is due at the end of the lecture (11 am), on the stated due date. It is a good practice to note the collaborator in your work if there has been any. However, the work that is turned in must be your own. You are encouraged to seek advice from TAs and collaborate with other students to work through homework problems. Homework is intended to show you how well you are progressing in learning the course material. The term grade will be a weighted average of exams, term paper and homework grades. There will be two in-class midterm quizzes (1 hour long), and a comprehensive final exam (3 hours long) at the end of the term. Office hours by the TA will be scheduled to help you in exams and homeworks. Weekly homework problem sets will be assigned each week to be handed in and graded. Optional tutorials will also be scheduled to review mathematical concepts and other tools (Comsol FEMLAB) needed in this course. Readings will be drawn from a variety of primary and text sources as indicated in the lecture schedule. Class StructureĢ0.330/2.793/6.023 will be taught in lecture format (3 hours/week), but with liberal use of class examples to link the course material with various biological issues. Principles of Colloid and Surface Chemistry. Baldock, UK: Research Studies Press, 2002. AC Electrokinetics: Colloids and Nanoparticles. Cellular Biophysics - Volume 1: Transport. New York, NY: Cambridge University Press, 2005. Physicochemical Hydrodynamics: An Introduction. Upper Saddle River, NJ: Prentice Hall, 1989. Additional Texts with Assigned Readings (not required to purchase) East Rutherford, NJ: Prentice Hall, 2003. Transport Phenomena in Biological Systems. Textbooks and Reference Materials Required Text (to purchase) Topic Outline Part I: Mechanical Driving Forces It is intended for undergraduate students who have taken a course in differential equations (18.03), an introductory course in molecular biology, and a course in transport, fluid mechanics, or electrical phenomena in cells (e.g. This course develops and applies scaling laws and the methods of continuum mechanics to biomechanical phenomena over a range of length scales, from molecular to cellular to tissue or organ level. Tutorials (optional): 1 session / week, 1 hour / session References are provided for further study.Lectures: 3 sessions / week, 1 hour / session Advanced topics covered include transport in the kidney, oxygen transport, receptor-mediated processes, cell adhesion, transport of drugs in tumors, and whole body pharmacokinetic models. This book can be used for both introductory and advanced courses. The problems at the end of each chapter require either analytical solution or numerical solution using MATLAB. An appendix provides an overview of relevant mathematical concepts used in the text. The introductory chapter presents a brief overview of transport processes at the cell and tissue level and relevant concepts in cell biology and physiology are presented throughout the text. Examples and problems elaborate on the concepts in the text or develop new concepts. In order to provide students with a firm understanding of biological transport processes, engineering concepts are provided within the context of specific biological problems. The book consists of four sections, which cover physiological fluid mechanics, mass transport, biochemical interactions and reactions and the effect of mass transfer, and transport in organs and whole organisms. Transport Phenomena in Biological Systems provides an introduction to the integrated study of transport processes and their biological applications. The efficient transport of molecules is essential for the normal function of cells and organs and the design of devices for medical applications and biotechnology.
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